Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 26, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

Dendritic cells from bench to bedside and back.

G J Adema1

  • 1Department of Tumorimmunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. g.adema@ncmls.ru.nl

Immunology Letters
|January 6, 2009
PubMed
Summary

Dendritic cells (DCs) are key immune sentinels that bridge innate and adaptive immunity. Their activation state determines whether the body mounts an immune response or establishes tolerance, impacting disease and transplantation outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MitoTam induces ferroptosis and increases radiosensitivity in head and neck cancer cells.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2024
Same author

Radiotherapy induces an increase in serum antioxidant capacity reflecting tumor response.

Clinical and translational radiation oncology·2024
Same author

Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer.

Cancer & metabolism·2023
Same author

Sialic acid blockade in dendritic cells enhances CD8<sup>+</sup> T cell responses by facilitating high-avidity interactions.

Cellular and molecular life sciences : CMLS·2022
Same author

Generation of αCD11b-CpG antibody conjugates for the targeted stimulation of myeloid cells.

Journal of controlled release : official journal of the Controlled Release Society·2021
Same author

A systems genomics approach identifies <i>SIGLEC15</i> as a susceptibility factor in recurrent vulvovaginal candidiasis.

Science translational medicine·2019

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are potent antigen-presenting cells crucial for immune regulation.
  • DCs link innate and adaptive immunity by interacting with various immune cells and producing interferons.
  • Different DC subsets exist, including myeloid-DCs (MDCs), plasmacytoid-DCs (PDCs), and Langerhans cells (LC).

Purpose of the Study:

  • To elucidate the pivotal role of dendritic cells in orchestrating immune responses and peripheral tolerance.
  • To highlight the influence of DC activation state on immunological outcomes.
  • To explore the mechanisms by which DCs integrate inflammatory and inhibitory signals.

Main Methods:

  • Review of existing literature on dendritic cell function and immune regulation.
  • Analysis of mouse models demonstrating the impact of DC activation states on immunity and tolerance.

More Related Videos

Culture of myeloid dendritic cells from bone marrow precursors
06:39

Culture of myeloid dendritic cells from bone marrow precursors

Published on: July 25, 2008

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
12:08

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Published on: May 17, 2019

Related Experiment Videos

Last Updated: Jun 26, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

Culture of myeloid dendritic cells from bone marrow precursors
06:39

Culture of myeloid dendritic cells from bone marrow precursors

Published on: July 25, 2008

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
12:08

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Published on: May 17, 2019

  • Discussion of the role of Toll-like receptors (TLRs) and inhibitory signals in DC programming.

    • Main Results:

    • DC activation, or maturation, induced by pathogen-associated molecular patterns (PAMPs) via Toll-like receptors (TLRs), leads to immunity.
    • Immune-inhibitory signals, such as IL-10 and corticosteroids, induce tolerogenic DCs, promoting tolerance.
    • The activation state of DCs dictates outcomes in models of infection, cancer, and transplantation.

    Conclusions:

    • Dendritic cells function at the critical interface between immunity and peripheral tolerance.
    • Modulating DC activation states holds potential for therapeutic strategies in autoimmunity, cancer, and transplantation.
    • Understanding DC subsets and their signaling pathways is essential for controlling immune responses.