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Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells

Yasir Hasan Siddique1, Mohammad Afzal

  • 1Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P. 202 002, India. yasir_hasansiddique@rediffmail.com

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|January 6, 2009
PubMed

Insights

Apigenin demonstrated antigenotoxic effects, protecting mouse bone marrow cells from mitomycin C-induced damage. This study found apigenin significantly reduced sister chromatid exchanges and chromosomal aberrations, indicating a protective role.

Area of Science:

  • Toxicology
  • Genetics
  • Pharmacology

Background:

  • Genotoxicity poses a significant health risk.
  • Mitomycin C is a known genotoxic agent.
  • Apigenin is a natural flavonoid with potential therapeutic properties.

Purpose of the Study:

  • To investigate the antigenotoxic potential of apigenin.
  • To evaluate apigenin's protective effects against mitomycin C-induced genotoxicity.
  • To assess apigenin's safety at tested doses.

Main Methods:

  • Assessing sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) in mouse bone marrow cells.
  • Administering apigenin at doses of 10, 20, and 40 mg/kg body weight.
  • Co-administering mitomycin C (2 mg/kg body weight) with apigenin.

Main Results:

  • Apigenin was found to be non-genotoxic at all tested doses.
  • A significant reduction in SCEs and CAs was observed when apigenin was co-administered with mitomycin C.
  • Apigenin demonstrated a protective effect against mitomycin C-induced genotoxicity.

Conclusions:

  • Apigenin exhibits significant antigenotoxic properties.
  • Apigenin can protect against mitomycin C-induced genotoxicity in mouse bone marrow cells.
  • Apigenin is a promising candidate for further investigation as a chemoprotective agent.

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