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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jun 26, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Kienböck's disease.

Pedro K Beredjiklian1

  • 1Rothman Institute, Philadelphia, PA 19107, USA. info@rothmaninstitute.com

The Journal of Hand Surgery
|January 6, 2009
PubMed
Summary

Kienböck's disease, or osteonecrosis of the lunate, causes chronic wrist pain. While its cause is unknown, surgical options like radial shortening osteotomy offer long-term management for this debilitating condition.

Area of Science:

  • Orthopedics
  • Hand Surgery
  • Wrist Biomechanics

Background:

  • Kienböck's disease (osteonecrosis of the lunate) is a progressive condition causing wrist pain and dysfunction.
  • The exact etiology remains unidentified, with suspected mechanical, vascular, and traumatic factors.
  • The natural history and correlation between radiographic and clinical findings are poorly understood.

Purpose of the Study:

  • To review the current understanding of Kienböck's disease.
  • To discuss diagnostic challenges and treatment modalities.
  • To evaluate the long-term outcomes of surgical interventions.

Main Methods:

  • Review of existing literature on Kienböck's disease.
  • Analysis of treatment outcomes for surgical procedures.

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Last Updated: Jun 26, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

  • Discussion of disease progression and wrist mechanics.

    • Main Results:

    • Advances in understanding avascular progression and its impact on wrist mechanics.
    • Vascularized pedicled grafts show potential for early-stage disease, but require further study.
    • Radial shortening osteotomy and proximal row carpectomy demonstrate reliable long-term management for early and advanced Kienböck's disease, respectively.

    Conclusions:

    • Kienböck's disease remains a challenging clinical problem with an unidentified etiology.
    • Surgical interventions, including radial shortening osteotomy and proximal row carpectomy, offer effective long-term management options.
    • Further research is needed to validate newer surgical techniques and fully understand disease progression.