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Updated: Jun 26, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
Alterations of coagulation in metformin intoxication
Baris Akinci1, Serkan Yener, Goksel Bengi
1Division of Endocrinology and Metabolism, Dokuz Eylul University Medical School, Inciralti, Izmir, Turkey. baris.akinci@deu.edu.tr
Abstract:
It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery. Our results indicate that both the levels of coagulation proteins synthesized by the liver and the anti-coagulant activity decrease temporarily in metformin intoxication. Nevertheless, no change in the coagulation factors secreted by the endothelium were observed.
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