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[New development in bisphosphonate treatment. Bisphosphonates and gastrointestinal adverse effects]
1Osaka City University Medical School, Post Graduate School of Medicine, Geriatric Medicine, Japan.
Abstract:
Endoscopic examination suggested gastric mucosal damage by NSAID is more serious than that of bisphosphonates. In addition, the incidence of GI-adverse effects (AEs) is reported to be insignificant, if the incidence is adjusted by history of peptic ulcer, drugs for comorbidity, sex, age and/or ways of evaluation of the AEs. The anxiety for taking medication under empty stomach may contribute to the increase of GI-AEs. Some consideration must be taken for patients with past history of peptic ulcer, and/or drug user such as NSAIDs.
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