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Updated: Aug 17, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Dynamic model of 99mTc-labelled lipoprotein accumulation in rabbit liver
Anisimova OYu1, E A Volynskaya, T I Kuzmina
1Institute of Experimental Cardiology, Academy of Medical Sciences of the USSR, Moscow.
Abstract:
To create a mathematical model to describe the receptor-mediated accumulation of 99mTc-labelled lipoproteins in rabbit liver, a set of differential equations was devised for the simplest case: that involving one ligand and one receptor. Normal and hypercholesterolemic rabbits were included in gammascintigraphic trials as having normal and reduced numbers, respectively, of liver low-density lipoprotein (LDL) receptors. The system described may have clinical applications as a quick and effective method of assessment of LDL uptake by the liver.

