Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers, unexplained...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough.

Surgical endoscopy·2025
Same author

Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough.

Surgical endoscopy·2025
Same author

Revisiting Proton Pump Inhibitors as Chemoprophylaxis Against the Progression of Barrett's Esophagus.

Current gastroenterology reports·2023
Same author

Heartburn, Nausea, and Vomiting During Pregnancy.

The American journal of gastroenterology·2022
Same author

Cryoballoon ablation for gastric pouch and/or outlet reduction in patients with weight regain post Roux-en-Y gastric bypass.

Endoscopy·2020
Same author

Follow-up of Incidentally Detected Pancreatic Cystic Neoplasms: Do Baseline MRI and CT Features Predict Cyst Growth?

Radiology·2019
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
Same journal

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique
06:31

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique

Published on: January 10, 2013

Confocal endomicroscopy.

Kerry Dunbar1, Marcia Canto

  • 1Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21205, USA. kdunbar@jhmi.edu

Current Opinion in Gastroenterology
|January 6, 2009
PubMed
Summary
This summary is machine-generated.

Confocal laser endomicroscopy offers in-vivo histology for gastrointestinal disorders. This advanced imaging technique aids in diagnosing neoplasia and understanding disease mechanisms, expanding endoscopic applications.

More Related Videos

Video-rate Scanning Confocal Microscopy and Microendoscopy
14:10

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
13:49

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Related Experiment Videos

Last Updated: Jun 26, 2026

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique
06:31

Probe-based Confocal Laser Endomicroscopy of the Urinary Tract: The Technique

Published on: January 10, 2013

Video-rate Scanning Confocal Microscopy and Microendoscopy
14:10

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
13:49

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Area of Science:

  • Gastrointestinal Endoscopy
  • Medical Imaging
  • In-vivo Histology

Background:

  • Confocal laser endomicroscopy (CLE) is an emerging endoscopic imaging modality.
  • It allows for real-time, in-vivo histological examination of the gastrointestinal mucosa.
  • Interest in CLE for in-vivo diagnosis of GI disorders has significantly increased.

Purpose of the Study:

  • To review recent advancements in confocal laser endomicroscopy.
  • To discuss the expanding clinical and research applications of CLE.
  • To explore the future potential of this technology in gastroenterology.

Main Methods:

  • Review of recent literature on confocal laser endomicroscopy.
  • Analysis of current applications in diagnosing gastrointestinal conditions.
  • Discussion of emerging technologies and future directions.

Main Results:

  • CLE aids in localizing intraepithelial neoplasia in chronic ulcerative colitis.
  • It enables targeted mucosal biopsies when combined with chromoendoscopy.
  • CLE demonstrates potential for accurate neoplasia diagnosis in the esophagus, stomach, colon, and bile duct.
  • In-vivo visualization of epithelial abnormalities, like intraepithelial bacteria, enhances understanding of disease pathogenesis.
  • Development of fluorescent peptide markers for targeted neoplasia visualization is ongoing.

Conclusions:

  • Confocal endomicroscopy is a rapidly developing field within gastrointestinal endoscopy.
  • CLE possesses expanding clinical and research applications.
  • The technology holds promise for improved diagnosis and understanding of gastrointestinal diseases.