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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
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Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Celiac disease.

Carlo Catassi1, Alessio Fasano

  • 1Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Current Opinion in Gastroenterology
|January 6, 2009
PubMed
Summary
This summary is machine-generated.

Celiac disease affects approximately 1% of the global population and is a valuable model for studying autoimmunity. Advances in genetics and pathogenesis are paving the way for new therapies beyond the gluten-free diet.

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Published on: September 22, 2019

Area of Science:

  • Immunology
  • Gastroenterology
  • Genetics

Background:

  • Celiac disease is a complex autoimmune disorder triggered by gluten ingestion.
  • Recent advancements have deepened our understanding of its clinical, epidemiological, and genetic facets.

Purpose of the Study:

  • To review significant research contributing to the current knowledge of celiac disease.
  • To highlight celiac disease as a model for autoimmunity research.

Main Methods:

  • Literature review of recent clinical, epidemiological, genetic, and therapeutic studies on celiac disease.

Main Results:

  • Celiac disease prevalence is ~1% worldwide, not limited to Caucasians.
  • Genetic factors beyond HLA, including those in immunity and intestinal barrier function, are implicated.
  • Novel therapies targeting celiac disease pathogenesis are in late-stage development.

Conclusions:

  • New findings are expected to significantly impact celiac disease diagnosis and clinical management.
  • Celiac disease serves as a unique model for understanding autoimmune disease pathogenesis.