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Updated: Jun 26, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
Published on: August 30, 2020
Antiepileptic drugs in aneurysmal subarachnoid hemorrhage
Alexander Y Zubkov1, Eelco F M Wijdicks
1Division of Critical Care Neurology, Mayo Clinic, and Neurology/Neurosurgery Intensive Care Unit, Saint Marys Hospital, Rochester, MN, USA.
Abstract:
Seizures may occur during or soon after rupture of an intracranial aneurysm. The use of antiepileptic drugs (AEDs) is a controversial issue. The overall conclusions from 2 recent studies in aneurysmal subarachnoid hemorrhage are that 1) many patients receive AEDs but should not; 2) long-term use is associated with worse outcome; and 3) short-term use is safer. Phenytoin may not be the first choice for seizure prophylaxis; newer AEDs such as levetiracetam might be more helpful in prevention and treatment of seizures.
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