Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acetylcholinesterase (AChE) is an important link in the apoptotic pathway induced by hyperglycemia in Y79 retinoblastoma cell line.

Frontiers in molecular neuroscience·2012

Same author

Prenatal diagnosis of dacryocystocele.

Eye (London, England)·2007

Same author

The response of retrobulbar vasculature to hypercapnia in primary open-angle glaucoma and ocular hypertension.

Ophthalmic research·2007

Same author

Prognostic factors for visual acuity improvement after intravitreal triamcinolone injection.

Eye (London, England)·2006

Same author

[Therapeutic penetrating keratoplasty for microbial keratitis].

Harefuah·2006

Same author

Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract.

Eye (London, England)·2004

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Orthokeratology associated microbial keratitis.

R Shehadeh-Masha'our¹, F Segev, I S Barequet

¹Bnai Zion Medical Center, Faculty of Medicine Technion, Haifa, Israel.

European Journal of Ophthalmology

|January 6, 2009

Summary

Overnight orthokeratology can lead to microbial keratitis, a serious eye infection. Prompt treatment is crucial, but corneal scarring can impair vision long-term.

More Related Videos

Conjunctival Commensal Isolation and Identification in Mice

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

Related Experiment Videos

Last Updated: Jun 26, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Conjunctival Commensal Isolation and Identification in Mice

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

Area of Science:

Ophthalmology
Microbiology
Corneal Disease

Background:

Overnight orthokeratology (ortho-k) is a vision correction method using rigid gas permeable lenses worn during sleep.
Microbial keratitis is a significant risk associated with contact lens wear, including ortho-k.

Observation:

This study reports on four cases of microbial keratitis in patients undergoing overnight orthokeratology.
Patients presented with central or paracentral corneal ulcers and varying visual acuity, from 20/30 to hand motion.

Findings:

Pseudomonas aeruginosa was identified in all cases, cultured from corneal scrapings or lens storage solutions.
All infections resolved with intensive topical antimicrobial therapy.
Despite successful treatment, all patients developed corneal scarring, impacting final best-corrected visual acuity (ranging from 20/25 to 20/200).

Implications:

Infectious keratitis is a sight-threatening complication of overnight orthokeratology.
Ophthalmologists and eye care practitioners must recognize this risk and counsel patients on rigorous lens hygiene.
Early detection and prompt medical intervention are essential to manage ortho-k-associated microbial keratitis and minimize visual sequelae.