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Updated: Jun 26, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Catalyzed vinylogous Mukaiyama aldol reactions with controlled enantio- and diastereoselectivities
Marcus Frings1, Iuliana Atodiresei, Jan Runsink
1Institut für Organische Chemie der RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany.
Abstract:
In control: A new catalytic vinylogous Mukaiyama aldol reaction provides products with high diastereo- and enantioselectivities (up to 99 % de and ee; see scheme). The relative and absolute stereochemistry of a representative product was rigorously assigned by NMR and CD spectroscopies (measured and calculated), X-ray diffraction, and quantum-chemical calculations.
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