Related Experiment Video
Updated: Jun 26, 2026
Implementation of a Nonlinear Microscope Based on Stimulated Raman Scattering
Published on: July 6, 2019
Improving surface-enhanced Raman scattering effect using gold-coated hierarchical polystyrene bead substrates
Clement Yuen1, Wei Zheng, Zhiwei Huang
1National University of Singapore, Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, Singapore 117576.
Abstract:
We report a novel postgrowth microwave heating implementation by selectively modifying hierarchical polystyrene (PS) bead substrates coated with gold (Au) films to effectively improve the surface-enhanced Raman scattering (SERS) effect on the analytes. The SERS signal of probe molecule rhodamine 6G (Rh 6G) on the microwave-treated Au-PS substrates can be improved by 10-fold, while the detection limit of Rh 6G in concentration can be enhanced by two orders of magnitude compared to the as-growth substrates. The high-quality SERS spectrum of saliva can also be acquired using the modified substrates, demonstrating the potential for the realization of the high-performance SERS substrates for biomedical applications.
