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Related Concept Videos

Introduction to Language of Pathophysiology l01:25

Introduction to Language of Pathophysiology l

Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like pain), laboratory test...
Introduction to Language of Pathophysiology ll01:17

Introduction to Language of Pathophysiology ll

This lesson explores key terms that describe how diseases progress, their outcomes, and their distribution in populations.Diagnostic tests identify diseases and monitor treatment. These include blood and urine tests, biopsies, imaging (X-ray, MRI), and detection of infectious agents.Remission is a reduction or disappearance of symptoms.Exacerbation refers to the worsening of symptoms, such as increased wheezing during an asthma attack.A precipitating factor triggers an acute episode, while a...
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Fixation and Sectioning

Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
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Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
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MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

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Related Experiment Video

Updated: Jun 26, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

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Published on: November 5, 2019

How does a pathologist make a diagnosis?

Gil Patrus Pena1, José de Souza Andrade-Filho

  • 1Servico de Anatomia Patologica, Hospital Felicio Rocho, Belo Horizonte, Minas Gerais, Brazil. gilpena@gold.com.br

Archives of Pathology & Laboratory Medicine
|January 7, 2009
PubMed
Summary

This study proposes a model for pathologic diagnosis, outlining cognitive, communicative, normative, and medical conduct domains. This framework aids in understanding diagnostic variations and improving pathology training.

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Area of Science:

  • Pathology
  • Medical Diagnostics

Background:

  • Pathologic diagnosis is a complex process rarely discussed in depth.
  • Existing educational models rely on apprenticeship, lacking a structured theoretical framework.
  • A lack of a formal model hinders objective discussions on diagnostic processes and variations.

Purpose of the Study:

  • To propose a comprehensive model for the pathologic diagnostic process.
  • To provide a theoretical framework for understanding diagnostic activities.
  • To enhance pathology education and identify areas for improvement.

Main Methods:

  • A conceptual model is proposed, integrating four key domains: cognitive, communicative, normative, and medical conduct.
  • The cognitive domain includes perception, attention, memory, hypothesis generation, and verification.
  • Communicative, normative (technical, rational, consensual rules), and medical conduct aspects are also detailed.

Main Results:

  • The proposed model views diagnosis as an action plan with distinct domains.
  • Cognitive processes are detailed, alongside communication skills for supporting conclusions.
  • The model incorporates technical, rational, and peer-consensus rules, and evaluates diagnosis within medical conduct.

Conclusions:

  • Understanding the diagnostic process theoretically benefits pathology as a science and specialty.
  • The model facilitates analysis of diagnostic variations and errors, enabling targeted remedies.
  • This framework can enhance pathology training by focusing on specific skill development.