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Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Related Experiment Video

Updated: Jun 26, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Drug-eluting stent thrombosis.

Barbara E Stähli1, Giovanni G Camici, Felix C Tanner

  • 1Cardiovascular Research, Physiology Institute, University of Zürich, Zurich, Switzerland.

Therapeutic Advances in Cardiovascular Disease
|January 7, 2009
PubMed
Summary

Stent thrombosis, a serious complication after stent implantation, occurs with both drug-eluting stents (DES) and bare-metal stents (BMS). This review examines the causes of stent thrombosis, focusing on DES prothrombotic effects.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomaterials Science

Background:

  • Stent thrombosis is a rare but severe complication post-stent implantation, linked to high morbidity and mortality.
  • Drug-eluting stents (DES) have not decreased stent thrombosis rates compared to bare-metal stents (BMS), despite reducing restenosis.
  • Pathogenesis involves patient, lesion, and procedure factors, alongside stent thrombogenicity.

Purpose of the Study:

  • To review clinical evidence and pathophysiological mechanisms of stent thrombosis in DES.
  • To highlight the prothrombotic effects specifically associated with DES.

Main Methods:

  • Literature review of clinical studies and research on stent thrombosis.
  • Analysis of pathophysiological mechanisms contributing to stent thrombosis.

More Related Videos

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
11:01

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
11:01

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

  • Focus on drug-eluting stent (DES) characteristics and their thrombotic potential.

    • Main Results:

    • Stent thrombosis remains a significant risk despite advances like DES.
    • Early cessation of dual antiplatelet therapy is a key risk factor.
    • The inherent thrombogenicity of DES contributes to stent thrombosis.

    Conclusions:

    • Understanding stent thrombosis mechanisms, particularly with DES, is crucial for patient outcomes.
    • Further research into stent design and material is needed to mitigate thrombotic risks.
    • Optimizing antiplatelet therapy duration and adherence is vital in preventing stent thrombosis.