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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Cardiovascular disease in chronic kidney disease

Anita M Saran1, Thomas D DuBose

  • 1Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. asaran@wfubmc.edu

Therapeutic Advances in Cardiovascular Disease
|January 7, 2009
PubMed

Insights

Kidney disease, including chronic kidney disease (CKD), significantly increases cardiovascular disease (CVD) risk. Early screening and aggressive management of risk factors in CVD patients with CKD are crucial for better outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Kidney disease, indicated by reduced glomerular filtration rate (GFR) and proteinuria, is an independent risk factor for cardiovascular disease (CVD).
  • The risk of CVD and mortality increases with the severity of kidney disease.
  • Early detection and management of chronic kidney disease (CKD) are vital for slowing disease progression and reducing proteinuria.

Purpose of the Study:

  • To highlight the independent association between kidney disease and increased cardiovascular disease (CVD) risk.
  • To recommend early screening and management strategies for CKD in patients with CVD.
  • To emphasize the need for further research into non-traditional risk factors and cardiovascular interventions in CKD patients.

Main Methods:

  • Screening for CKD in all patients with CVD.
  • Calculating estimated glomerular filtration rate (eGFR).
  • Evaluating proteinuria using a spot urine albumin-to-creatinine ratio (ACR).

Main Results:

  • Kidney disease is independently linked to higher rates of cardiovascular disease (CVD) and mortality.
  • Disease severity correlates with increased CVD risk.
  • Aggressive management of traditional cardiovascular risk factors is recommended for this high-risk group.

Conclusions:

  • CKD requires early recognition and treatment to slow progression and reduce proteinuria.
  • Screening for CKD in CVD patients is recommended, including eGFR and ACR assessment.
  • Rigorous control of hypertension (ACEI/ARB use), hyperglycemia, hyperlipidemia, and smoking cessation are essential.

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