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Updated: Jun 26, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q
Carole Ober1, Alex S Nord, Emma E Thompson
1Department of Human Genetics, University of Chicago, Chicago, IL, USA. c-ober@genetics.uchicago.edu
Abstract:
Plasma lipoprotein(a) (Lp[a]) level is an independent risk factor of cardiovascular disease that is under strong genetic control. We conducted a genome-wide association study of plasma Lp(a) in 386 members of a founder population that adheres to a communal lifestyle, proscribes cigarette smoking, and prepares and eats meals communally. We identified associations with 77 single nucleotide polymorphisms (SNPs) spanning 12.5 Mb on chromosome 6q26-q27 that met criteria for genome-wide significance (P
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