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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

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Intrathecal methotrexate-induced acute chorea.

Dilek Necioğlu Orken¹, Yldz Yldrmak, Gülay Kenangil

¹Departments of Neurology, Sişli Etfal Education and Research Hospital, Istanbul, Turkey. orkenada@superonline.com

Journal of Pediatric Hematology/Oncology

|January 7, 2009

Summary

Intrathecal methotrexate prevents central nervous system complications in acute lymphoblastic leukemia. A patient experienced acute chorea after this therapy but fully recovered, highlighting a rare neurological side effect.

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Area of Science:

Neurology
Oncology
Pharmacology

Background:

Intrathecal methotrexate is a standard treatment for central nervous system (CNS) prophylaxis in acute lymphoblastic leukemia (ALL).
This method aims to prevent leukemia spread to the brain and spinal cord.

Observation:

A case study describes a patient who received intrathecal methotrexate therapy for ALL.
The patient developed acute chorea, a movement disorder characterized by involuntary, jerky movements, following the final dose of treatment.

Findings:

The patient's chorea symptoms resolved completely following the cessation of intrathecal methotrexate.
This suggests a potential, albeit rare, neurological adverse effect of intrathecal methotrexate therapy.

Implications:

This case highlights the importance of monitoring for neurological side effects during and after intrathecal methotrexate treatment in ALL patients.
Further investigation may be warranted to understand the mechanism and incidence of methotrexate-induced chorea.
Awareness of this potential complication can aid in timely diagnosis and management, improving patient outcomes.