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Updated: Jun 26, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Enantioselective synthesis of benzimidazolyl quinoxalinones on soluble polymer support using focused microwave
Kaushik Chanda1, Jaren Kuo, Chih-Hau Chen
1Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan 300-10, ROC.
Abstract:
Focused microwave irradiation has been applied to a multistep synthetic sequence of reactions designed to generate benzimidazolyl quinoxalinones using a soluble polymer support. They were obtained by the ipso-fluoro (S(N)Ar) displacement of the immobilized ortho-nitro fluoro benzimidazoles with chiral alpha amino esters under microwave irradiation. Intermediate chiral organic-polymer conjugates when subjected to neutral reduction underwent a spontaneous intramolecular ring closure. Cleavage of the polymer support, at room temperature, did not cause any significant racemization resulting in the generation of a chiral molecular library with two points of structural diversity.
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