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Updated: Jun 26, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Highly diastereoselective anti-aldol reactions of glycolate titanium enolates
Dnyaneshwar Gawas1, Uli Kazmaier
1Institut für Organische Chemie, Universität des Saarlandes, 66123 Saarbrücken, Germany.
Abstract:
Diastereoselective aldol reactions of enolates of alpha-hydroxy ester with different aldehydes are metal tunable, providing either anti- or syn- products. The highest anti-selectivities were obtained with TiCl(OiPr)(3), while Ti(OiPr)(4) provides the opposite syn-products.
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