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Rhabdomyomatous mesenchymal hamartoma presenting on a digit.

Nooshin K Brinster¹, Evan R Farmer

¹Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0662, USA. nbrinster@mcvh-vcu.edu

Journal of Cutaneous Pathology

|January 8, 2009

Summary

Rhabdomyomatous mesenchymal hamartoma is a rare skin lesion. This case report details an unusual presentation on the great toe of an adult, expanding known locations for this condition.

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Area of Science:

Dermatology
Pathology
Histology

Background:

Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare benign dermal lesion.
It is characterized by a proliferation of skeletal muscle, adipose tissue, and collagen.
RMH is predominantly reported in infants and children, typically affecting the head and neck region.

Observation:

This report presents a case of RMH in a 36-year-old male patient.
The lesion was located on the great toe, an atypical site for RMH.
This represents one of the few documented cases of RMH outside the head and neck area.

Findings:

Histopathological examination confirmed the diagnosis of RMH.
The presence of skeletal muscle, adipocytes, and collagen confirmed the characteristic composition.
The adult age and distal extremity location are notable deviations from typical presentations.

Implications:

Awareness of RMH is crucial for dermatologists and pathologists.
The differential diagnosis of dermal lesions should include RMH, even in atypical locations and age groups.
Recognizing RMH is important due to its potential association with congenital syndromes and its unusual localization patterns.