Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Antiasthma Drugs: β2-Adrenoceptor Agonists

Antiasthma Drugs: β₂-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...

Drugs Used in Lower Respiratory Disorders: Overview

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sex differences in expression of oestrogen receptor α but not androgen receptor mRNAs in the foetal lamb brain.

Journal of neuroendocrinology·2014

Same author

Traditional fish intake and fatty acid composition in fish consuming and non-fish consuming populations.

Asia Pacific journal of clinical nutrition·2014

Same author

Factors associated with nonresponse to a computer-tailored asthma management program for urban adolescents with asthma.

The Journal of asthma : official journal of the Association for the Care of Asthma·2010

Same author

Severe asthma: approach and management.

Postgraduate medical journal·2008

Same author

Polycyclic aromatic hydrocarbons in the ambient air of Jeedimetla Industrial Development Area-Hyderabad.

Journal of environmental science & engineering·2006

Same author

Indoor air quality at Salarjung Museum, Hyderabad, India.

Environmental monitoring and assessment·2005

Same journal

Impact of pharmacist-initiated educational interventions on improving medication reconciliation practice in geriatric inpatients during hospital admission in Vietnam.

Journal of clinical pharmacy and therapeutics·2022

Same journal

Evaluation of off-label anti-vascular endothelial growth factor and steroid implant medication uses in macular edema due to retinal vein occlusion in Turkey.

Journal of clinical pharmacy and therapeutics·2022

Same journal

A descriptive analysis of pharmacological management of aggression and/or agitation in patients with traumatic brain injury in a Southwest Virginia inpatient population.

Journal of clinical pharmacy and therapeutics·2022

Same journal

Effects of caregiver counselling on medication persistence and adherence in patients with dementia at a pharmacist-managed clinic: A pilot study.

Journal of clinical pharmacy and therapeutics·2022

Same journal

The 50% and 95% effective doses of remimazolam tosilate with adjuvant sufentanil for sedation in patients with liver cirrhosis undergoing oesophagogastric varices screening endoscopy.

Journal of clinical pharmacy and therapeutics·2022

Same journal

Tumour necrosis factor inhibitor combined with intravenous immunoglobulin and heparin for treatment of recurrent spontaneous abortion: A two-centre, retrospective, cohort study.

Journal of clinical pharmacy and therapeutics·2022

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Inhaled corticosteroids for asthma: are they all the same?

A P Baptist¹, R C Reddy

¹Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA.

Journal of Clinical Pharmacy and Therapeutics

|January 8, 2009

Summary

This summary is machine-generated.

This study compares inhaled corticosteroids (ICS) for asthma, highlighting differences in formulations and delivery systems. These variations impact therapeutic efficacy and safety profiles for patients.

Related Experiment Videos

Last Updated: Jun 26, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Area of Science:

Pharmacology
Respiratory Medicine

Background:

Inhaled corticosteroids (ICS) are a cornerstone therapy for asthma management.
Variations exist among currently available ICS in terms of formulation and delivery systems.

Purpose of the Study:

To evaluate similarities and differences among available ICS for asthma treatment.
To emphasize factors influencing the relative safety of these medications.

Main Methods:

A comprehensive literature search of PubMed was conducted for relevant reviews and original articles.
Information from retrieved studies was synthesized and critically evaluated.

Main Results:

Differences in ICS formulations and delivery systems influence therapeutic efficacy and safety.
Prodrug formulations (ciclesonide, beclomethasone dipropionate) minimize oropharyngeal side effects.
Systemic absorption and metabolism vary, with rapid hepatic metabolism for most ICS and additional extrahepatic metabolism for ciclesonide.
High serum protein binding of ciclesonide and mometasone reduces extra-pulmonary glucocorticoid receptor stimulation.

Conclusions:

Despite similar mechanisms of action, ICS and their delivery systems exhibit distinct characteristics.
These differences can impact individual patient safety and therapeutic effectiveness.