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Antibiotic use in pulmonology wards of Chinese children's hospitals: 2002-2006

W Zhang1, X Liu, Y Wang

  • 1Beijing Children's Hospital, Capital Medical University, Beijing, China.

Journal of Clinical Pharmacy and Therapeutics
|January 8, 2009
PubMed

Insights

Antibiotic use in Chinese pediatric pulmonology wards varied significantly between hospitals from 2002-2006. Despite guidelines, prescribing patterns remained inconsistent, highlighting a need for improved antibiotic stewardship and compliance interventions.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic resistance is a growing global health concern.
  • Appropriate antibiotic use is crucial in pediatric care to prevent resistance.
  • Understanding prescribing patterns is essential for effective antibiotic stewardship.

Purpose of the Study:

  • To analyze antibiotic consumption patterns in pediatric pulmonology wards across four Chinese hospitals.
  • To evaluate antibiotic use trends between 2002 and 2006.
  • To identify variations in antibiotic prescribing practices.

Main Methods:

  • Utilized the Anatomical Therapeutic Chemical Classification/Defined Daily Doses (ATC/DDD) methodology.
  • Collected aggregate data on antibiotic use (ATC code-J01) for inpatients.
  • Expressed antibiotic consumption in DDD/100 bed-days.

Main Results:

  • Overall antibiotic consumption varied widely across the four hospitals (range: 49.9–83.7 DDD/100 bed-days).
  • Injectable antibiotics were frequently prescribed.
  • Significant differences in the quantity and types of antibiotics used were observed between hospitals.

Conclusions:

  • Substantial inter-hospital variability in antibiotic prescribing exists, even for similar conditions.
  • Factors like disease severity, regional resistance, and empiric treatment likely contribute to variations.
  • The Chinese Ministry of Health Antibiotic Guidelines (2004) did not significantly alter prescribing patterns during the study period (2002-2006).
  • Further studies comparing drug use to guidelines and targeted interventions are needed to improve antibiotic stewardship.
Abstract

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