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Formulation and Characterization of Bioactive Agent Containing Nanodisks

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Amphotericin B removal by plasma exchange.

¹Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, Washington, DC, USA. sqlew@gwu.edu

Journal of Clinical Pharmacy and Therapeutics

|January 8, 2009

Summary

Plasma exchange removed 40% of amphotericin B in a patient with liver and renal failure. This finding adds to the understanding of amphotericin B pharmacokinetics during critical illness.

Area of Science:

Pharmacokinetics
Critical Care Medicine
Nephrology

Background:

Amphotericin B is a critical antifungal agent.
Its use can be limited by toxicity and complex dosing.
High protein binding influences drug removal.

Observation:

A patient with concurrent liver and renal failure underwent plasma exchange.
Plasma exchange is a procedure that removes substances from blood plasma.
The procedure's impact on amphotericin B levels was assessed.

Findings:

Plasma exchange demonstrated a 40% reduction in amphotericin B levels.
This suggests significant removal of the drug during the procedure.
The patient's severe organ dysfunction likely contributed to these findings.

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Implications:

Plasma exchange may necessitate adjustments in amphotericin B dosing in critically ill patients.
Understanding drug removal is crucial for optimizing antifungal therapy.
Further research is needed to confirm these pharmacokinetic alterations.