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Related Experiment Videos

Frontiers in bone marrow transplantation.

E D Thomas1

  • 1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

Blood Cells
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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The use of radiolabeled anti-CD33 antibody to augment marrow irradiation prior to marrow transplantation for acute myelogenous leukemia.

Transplantation·1992
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Bone marrow transplantation: past experiences and future prospects.

Seminars in oncology·1992
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European journal of haematology·1992
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Mixed leukocyte culture reactivity and graft-versus-host disease in HLA-identical marrow transplantation for leukemia.

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Acceptance of the George M. Kober Medal.

Transactions of the Association of American Physicians·1992

This review covers early animal and human studies on marrow transplantation, summarizing its results for various diseases and outlining current research directions.

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Science

Background:

  • Early murine experiments and human studies demonstrated the potential of marrow transplantation.
  • Marrow transplantation has emerged as a critical therapeutic modality.

Purpose of the Study:

  • To review the historical development and foundational research of marrow transplantation.
  • To summarize the clinical outcomes of marrow grafting across diverse human diseases.
  • To highlight contemporary research trends and future prospects in the field.

Main Methods:

  • Comprehensive literature review of early murine experiments.
  • Analysis of human clinical studies on marrow transplantation.
  • Synthesis of reported results for various human diseases.

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Main Results:

  • Early research established the feasibility and potential of marrow transplantation.
  • Marrow grafting has shown efficacy in treating a range of human diseases.
  • Ongoing research is expanding the applications and refining techniques.

Conclusions:

  • Marrow transplantation has a significant history supported by early research.
  • The therapeutic application of marrow grafting is well-established for multiple conditions.
  • The field is dynamic, with active research driving future innovations.