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Substrate utilization during and after exercise in mild cystic fibrosis
Laurie Wideman1, Carol F Baker, Pam Kocher Brown
1Department of Exercise and Sport Science, University of North Carolina at Greensboro, Greensboro, NC 27412, USA. lauriewideman@uncg.edu
Medicine and Science in Sports and Exercise
|January 8, 2009
Summary
Adolescents with cystic fibrosis (CF) show similar substrate utilization during exercise compared to healthy peers. However, increased energy expenditure, particularly excess postexercise oxygen consumption (EPOC), suggests a need for higher caloric intake in CF patients.
Area of Science:
- Exercise Physiology
- Pediatric Pulmonology
- Metabolic Research
Background:
- Cystic Fibrosis (CF) impacts energy metabolism and physical capacity.
- Understanding substrate utilization and energy expenditure in adolescents with CF is crucial for nutritional management.
- Previous research has not fully elucidated exercise-related metabolic differences in this population.
Purpose of the Study:
- To compare substrate utilization and energy expenditure during maximal and submaximal exercise and recovery in adolescents with CF and healthy controls.
- To assess metabolic responses to varying exercise intensities and durations.
- To inform nutritional recommendations for adolescents with CF.
Main Methods:
- Ten clinically stable CF patients were matched with healthy controls based on BMI, age, gender, and Tanner stage.
- Subjects underwent VO2peak testing and 20-minute submaximal exercise trials at 50% VO2peak and fixed absolute power output (PO).
- Metabolic parameters, including respiratory quotient (RQ) and excess postexercise oxygen consumption (EPOC), were measured during exercise and 20-minute recovery.
Main Results:
- Similar respiratory quotient (RQ) values were observed between CF patients and controls during maximal exercise and recovery, despite significant differences in maximal PO, total work, and VO2peak.
- Submaximal exercise at a fixed absolute PO showed similar RQ values but higher heart rates and VO2 in CF adolescents.
- Excess postexercise oxygen consumption (EPOC) was significantly greater in CF patients after submaximal exercise at a fixed PO, but not after relative intensity exercise.
Conclusions:
- Macronutrient intake ratios do not require adjustment in adolescents with mild to moderate CF based on habitual physical activity.
- Total caloric intake may need to be increased in adolescents with CF to account for elevated EPOC.
- Nutritional strategies should consider the intensity and duration of habitual physical activity in CF management.
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