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HLA-DQB1* polymorphism and associations with dilated cardiomyopathy, inflammatory dilated cardiomyopathy and

Irene Portig1, Andrea Sandmoeller, Sabine Kreilinger

  • 1Department of Internal Medicine-Cardiology, Philipps University Marburg, Marburg, Germany. portig@med.uni-marburg.de

Autoimmunity
|January 8, 2009
PubMed

Insights

This study links specific HLA DQB1* alleles to myocarditis, a heart inflammation. Certain alleles are associated with myocarditis, distinguishing it from idiopathic dilated cardiomyopathy (DCM).

Area of Science:

  • Immunogenetics
  • Cardiology
  • Molecular Biology

Background:

  • Idiopathic dilated cardiomyopathy (DCM) has weak links to HLA class II alleles.
  • Systematic investigation of HLA class II alleles in DCM causes, particularly myocarditis, is lacking.

Purpose of the Study:

  • To investigate associations between HLA DQB1* alleles and different forms of DCM, including myocarditis.
  • To explore if HLA DQB1* alleles can differentiate between idiopathic and inflammatory DCM.

Main Methods:

  • HLA DQB1* allele typing using sequence-specific primer-polymerase chain reaction.
  • Analysis of patients with idiopathic DCM, myocarditis with normal function, and inflammatory DCM.
  • Comparison with cardiac disease-free controls and population controls.

Main Results:

  • Significant association of HLA DQB1*0303 with myocarditis without cardiac dysfunction.
  • Weaker associations found for HLA DQB1*0301 presence and HLA DQB1*06 absence in inflammatory DCM.
  • Potential of DQB1*02-DQB1*03 allelic combination to distinguish idiopathic from inflammatory DCM.

Conclusions:

  • Specific HLA DQB1* alleles are associated with myocarditis and inflammatory DCM.
  • HLA DQB1* alleles may serve as biomarkers to differentiate DCM subtypes.
  • Further prospective studies are needed to confirm these findings.

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