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Published on: February 10, 2012
Effect of nicotine polyestex gum on smoking cessation and quality of life
Suthat Rungruanghiranya1, Chatchai Ekpanyaskul, Yongyos Hattapornsawan
1Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand. suthat109@yahoo.com
Objective:
To determine the effectiveness and safety of the novel nicotine polyestex gum for smoking cessation, along with its impact on the quality of life (QOL).
Material And Method:
A double-blind, placebo-controlled, randomized clinical trial was conducted on 43 smokers. All of them received either nicotine gum or placebo. Only those who could quit completely and continuously by the end of 3 months were considered total abstinence. QOL was also measured using WHO questionnaires.
Results:
Treatment with nicotine polyestex gum resulted in significantly greater abstinence rate at 3 months compared with placebo (50% vs. 9%; p = 0.003). Adverse events were modest and not encountered more often than those seen in the placebo group. QOL at 3-months improved in both groups, but there was no statistically significant difference between the groups.
Conclusion:
Nicotine polyestex gum is effective and safe for smoking cessation. It is also associated with significant improvement in the QOL.
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