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Published on: September 6, 2017
[HLA-G alleles and risk of early pregnancy loss]
Olimpia Sipak-Szmigiel1, Cezary Cybulski, Elzbieta Ronin-Walknowska
1Klinika Medycyny Matczyno-Płodowej Pomorskiej Akademii Medycznej w Szczecinie ul. Unii Lubelskiej 1, 72-252 Szczecin.
Introduction:
To investigate whether HLA-G gene polymorphism is associated with adverse pregnancy outcome, we screened exons 2, 3, 4 of HLA-G gene in 59 women with reproductive failure and 36 fertile women. The HLA-G 10108 allele was more common in the group of examined women than in women from the control group (OR = 5,9; p = 0,09), but this difference was not statistically significant.
Results:
We conclude that the HLA-G 10108 allele might influence pregnancy outcome in the Polish population, but further studies are needed in this regard.
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