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Updated: Jun 26, 2026

Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
Femtosecond laser-induced ionization/dissociation of protonated peptides
Christine L Kalcic1, Tissa C Gunaratne, A Daniel Jones
1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Abstract:
Although tandem mass spectrometry has revolutionized the identification and structural characterization of peptides and proteins, future advances in comprehensive proteome analysis will depend on the development of improved methods for ion activation that yield greater sequence information, and with selective control over the fragmentation chemistry. This report presents initial findings that demonstrate the utility of a novel ion activation method using ultrashort (approximately 30 fs) laser pulses as a means to overcome the limitations of current technologies, while opening the door to solving significant challenges in protein and peptide analysis.
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