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Related Concept Videos

Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

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Updated: Jun 26, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Does Young's syndrome exist?

A K Arya1, H L Beer, J Benton

  • 1Department of Otolaryngology, Head and Neck Surgery, University Hospital Aintree, Liverpool, UK. arvind7@tesco.net

The Journal of Laryngology and Otology
|January 9, 2009
PubMed
Summary
This summary is machine-generated.

Young's syndrome, a triad of male infertility, azoospermia, and bronchiectasis, has limited evidence linking it to sinusitis. The condition

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Last Updated: Jun 26, 2026

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Published on: November 21, 2013

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Published on: December 4, 2021

Area of Science:

  • Otolaryngology
  • Infertility Medicine
  • Medical Syndromes

Background:

  • Young's syndrome is characterized by male infertility, azoospermia, bronchiectasis, and sinusitis.
  • While recognized in infertility, its role in sino-nasal disease is poorly understood.
  • The significance of the sinus component within this triad requires further investigation.

Purpose of the Study:

  • To investigate the relationship between sinusitis and Young's syndrome.
  • To analyze the current literature on the sinus component of Young's syndrome.

Main Methods:

  • A comprehensive review of published literature was conducted.
  • Analysis focused on the diagnostic criteria and emphasis on sinus disease in reported cases.

Main Results:

  • The diagnosis of sinusitis in Young's syndrome cases was often crude and poorly defined.
  • Most publications placed little emphasis on the sinus disease aspect.
  • Evidence linking Young's syndrome to significant sinus disease is limited.

Conclusions:

  • The prevalence of Young's syndrome appears to be declining.
  • Limited evidence supports Young's syndrome as a significant cause of sinus disease.
  • The term 'Young's syndrome' may refer to two distinct medical conditions.