Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
Overview of Biostatistics in Health Sciences01:19

Overview of Biostatistics in Health Sciences

Biostatistics involves the application of statistical techniques to scientific research in health-related fields, including biology and public health. These techniques are essential for designing studies, collecting data, and analyzing it to draw meaningful conclusions. Given the complexity of biological processes, particularly in studies involving human subjects, biostatistical methods are crucial for effectively organizing and interpreting data that might otherwise obscure underlying patterns...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Study on Form of Ar/Air ICP and A Microwave Diagnostics Based on the Hβ Spectrum Broadening].

Guang pu xue yu guang pu fen xi = Guang pu·2018
Same author

Higher Serum C Reactive Protein Determined C Reactive Protein Single-Nucleotide Polymorphisms Are Involved in Inherited Depression.

Psychiatry investigation·2018
Same author

Global investigation of an engineered nitrogen-fixing Escherichia coli strain reveals regulatory coupling between host and heterologous nitrogen-fixation genes.

Scientific reports·2018
Same author

Surveillance of Genetic Variations Associated with Antimalarial Resistance of Plasmodium falciparum Isolates from Returned Migrant Workers in Wuhan, Central China.

Antimicrobial agents and chemotherapy·2018
Same author

[Methods from Huangdi Neijing for treatment of hypertension].

Zhonghua wei zhong bing ji jiu yi xue·2018
Same author

E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells.

International journal of oncology·2018
Same journal

Amplification refractory mutation system polymerase chain reaction-capillary electrophoresis's applicability for newborn screening in dried blood spots of spinal muscular atrophy.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same journal

Comment on "Utilization of home-based traditional Chinese medicine in a homebound population under the integrated home-based medical care program in Taiwan".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same journal

Further considerations on early energy delivery and metabolic patterns in indirect calorimetry-guided nutrition for surgical ICU patients.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same journal

Response to "Comment on 'recent trends of LDL-C control and lipid-lowering therapy in patients with ASCVD in Taiwan: 2015-2020".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same journal

Comment on "Satisfaction with bladder management in community-dwelling patients with chronic spinal cord injury".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same journal

Comment on: SGLT2 inhibitors and geriatric syndromes in older adults with type 2 diabetes: A real-world cohort study.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems
06:18

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Published on: April 26, 2019

Statistical methods in translational medicine.

Shein-Chung Chow1, Siu-Keung Tse, Min Lin

  • 1Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|January 9, 2009
PubMed
Summary
This summary is machine-generated.

This study outlines strategies and statistical methods for assessing translation in pharmaceutical research, focusing on information translation from basic science to clinical practice. It emphasizes the critical role of statistics in ensuring reliable translational medicine outcomes.

More Related Videos

Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

Related Experiment Videos

Last Updated: Jun 26, 2026

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems
06:18

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Published on: April 26, 2019

Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

Area of Science:

  • Pharmaceutical research and development
  • Translational medicine
  • Clinical research statistics

Background:

  • Translational medicine bridges basic science discoveries with clinical applications for disease diagnosis, treatment, and prevention.
  • Effective translation requires robust statistical methodologies to ensure accuracy and reliability.
  • The study addresses translation across language, information, and technology within pharmaceutical R&D.

Purpose of the Study:

  • To present strategies and statistical considerations for evaluating translation in pharmaceutical research.
  • To focus on the statistical aspects of information translation from bench to bedside.
  • To review methods for selecting appropriate clinical study endpoints.

Main Methods:

  • Review of statistical strategies for assessing translation in language, information, and technology.
  • Detailed examination of statistical considerations for information translation (bench-to-bedside).
  • Discussion of statistical inference for animal-to-human model applicability and clinical endpoint selection.

Main Results:

  • Identified key statistical challenges and strategies in translational research.
  • Highlighted the importance of statistical rigor in validating basic discoveries for clinical use.
  • Reviewed various approaches for defining and selecting clinical study endpoints.

Conclusions:

  • Statistical methods are crucial for ensuring the accuracy and reliability of translational medicine.
  • Appropriate statistical strategies enhance the successful translation of research findings into clinical practice.
  • The study provides a framework for statistical considerations in pharmaceutical R&D translation.