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Updated: Jun 26, 2026

Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models
Published on: June 30, 2023
Mitochondrial DNA sequence variation and neurodegeneration
Michelangelo Mancuso1, Massimiliano Filosto, Daniele Orsucci
1Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, Pisa, Italy. mmancuso@inwind.it
Abstract:
Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria aimed at identifying genetic markers relating to ageing and neurodegenerative diseases. In this review, some of the major neurodegenerative disorders are highlighted and the role of mitochondrial haplogroups in the pathogenetic cascade leading to these diseases is discussed.
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