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Related Concept Videos

iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Related Experiment Video

Updated: Jun 26, 2026

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Chip-CE/MS using a flat low-sheath-flow interface.

Fu-An Li1, Ju-Li Huang, Guor-Rong Her

  • 1Department of Chemistry, National Taiwan University, Taipei, Taiwan.

Electrophoresis
|January 9, 2009
PubMed
Summary
This summary is machine-generated.

A novel chip-based capillary electrophoresis/electrospray ionization/mass spectrometry (CE/ESI/MS) interface was developed. This low-sheath-flow design enhances analytical capabilities for complex mixtures.

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A Microfluidic Chip for ICPMS Sample Introduction
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A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

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A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Mass Spectrometry

Background:

  • Coupling capillary electrophoresis (CE) with mass spectrometry (MS) is crucial for analyzing complex samples.
  • Existing chip-based CE/MS interfaces often face challenges with dead volume and emitter replacement.
  • Developing robust and efficient interfaces is essential for advancing analytical techniques.

Purpose of the Study:

  • To develop and characterize a novel chip-CE/ESI/MS interface with a low-sheath-flow design.
  • To improve the ease of emitter replacement in chip-based CE/MS systems.
  • To demonstrate the analytical utility of the developed interface for complex mixture analysis.

Main Methods:

  • Fabrication of a flat low-sheath-flow interface using PMMA components.
  • Construction of the CE interface using a wire-assisted epoxy-fixing method.
  • Integration of a connecting capillary with a tapered ESI sprayer for low dead volume liquid junction.

Main Results:

  • A functional chip-CE/ESI/MS interface with a low-sheath-flow design was successfully developed.
  • The interface allows for easy replacement of the electrospray ionization (ESI) emitter, a key advantage over existing designs.
  • Demonstrated analytical utility through the analysis of synthetic mixtures, including histamine antagonists and peptides.

Conclusions:

  • The developed low-sheath-flow chip-CE/ESI/MS interface offers improved performance and practicality.
  • The design facilitates efficient coupling of CE with ESI/MS, enabling sensitive analysis.
  • This microdevice represents a valuable tool for researchers in analytical chemistry and related fields.