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Updated: Jun 26, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
Published on: September 1, 2011
Chronic organophosphate (OP)-induced neuropsychiatric disorder is a withdrawal syndrome
De-Hong Tan1, Shuang-Qing Peng, Ying-Liang Wu
1Evaluation and Research Center for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, 20 Dong Da Jie Street, Fengtai District, Beijing 100071, PR China. tandehongsy@126.com
Abstract:
Chronic organophosphate-induced neuropsychiatric disorder is a less well-characterized syndrome, which is usually delay-occurred, persists long and is similar to the symptom of cholinergic deficit, its mechanism is unclear. The characteristics of chronic organophosphate-induced neuropsychiatric disorder are somewhat opposite to the direct action of OP pesticide, since withdrawal effect is usually opposite to the original effect of a drug, hypothesis that chronic organophosphate-induced neuropsychiatric disorder is a kind of withdrawal syndrome is suggested.
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