Related Experiment Video
Updated: Jun 26, 2026

12:59
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
Aging, exercise, and muscle protein metabolism
René Koopman1, Luc J C van Loon
1Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 10, 2009
Summary
Aging causes muscle loss, but exercise and proper nutrition can help older adults build muscle. Resistance training is effective for improving strength and function in the elderly.
Area of Science:
- Gerontology
- Exercise Physiology
- Nutritional Science
Background:
- Aging leads to sarcopenia, a loss of muscle mass and strength, increasing disease risk.
- This decline is linked to disrupted muscle protein turnover, with impaired synthesis response to stimuli.
- The blunted response to food intake is a key factor in age-related muscle loss.
Purpose of the Study:
- To investigate the impact of aging on skeletal muscle protein synthesis.
- To explore the role of nutrition and exercise in mitigating age-related muscle loss.
- To identify effective strategies for preserving muscle mass and function in the elderly.
Main Methods:
- Review of current research on aging, muscle protein synthesis, and anabolic stimuli.
- Analysis of studies examining the effects of food intake and physical activity on muscle mass.
- Evaluation of the efficacy of resistance exercise training in older adults.
Main Results:
- Basal muscle protein synthesis rates are similar in young and elderly individuals.
- The muscle protein synthetic response to food intake is reduced in the elderly.
- Exercise, particularly resistance training, stimulates muscle growth in older adults, dependent on nutrient timing.
Conclusions:
- The elderly retain the capacity for muscle protein synthesis in response to stimuli.
- Optimizing nutrition and exercise timing is crucial for combating age-related muscle decline.
- Further research is needed to develop targeted lifestyle interventions for elderly muscle health.
Related Concept Videos
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Overview of Protein Metabolism
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Exercise and Muscle Performance
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Muscle Recovery and Fatigue
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Mitochondria
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
