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Related Experiment Video

Updated: Jun 26, 2026

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
06:55

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Pediatric lung transplantation.

Stuart C Sweet1

  • 1Department of Pediatrics, Washington University, St. Louis, MO 63110, USA. sweet@kids.wustl.edu

Proceedings of the American Thoracic Society
|January 10, 2009
PubMed
Summary
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Pediatric lung transplantation offers a viable treatment for end-stage lung disease in children. Young children generally experience better outcomes, but adherence and bronchiolitis obliterans remain key challenges.

Area of Science:

  • Pediatric Pulmonology
  • Transplant Surgery
  • Immunology

Background:

  • Lung and heart-lung transplantation are crucial for pediatric end-stage pulmonary diseases.
  • Pediatric patients present unique challenges, including specific diagnoses and higher ventilation needs.
  • Infections pose significant complications before and after pediatric transplantation.

Purpose of the Study:

  • To review the current state and outcomes of pediatric lung and heart-lung transplantation.
  • To identify pediatric-specific challenges and areas for improvement in transplant care.
  • To discuss long-term outcomes and major complications in pediatric transplant recipients.

Main Methods:

  • Review of existing literature on pediatric lung and heart-lung transplantation.

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Last Updated: Jun 26, 2026

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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Published on: February 14, 2022

Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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  • Analysis of outcomes, complications, and age-specific differences in pediatric transplant recipients.
  • Discussion of challenges such as infection, rejection, and adherence.

    • Main Results:

    • Overall outcomes for pediatric lung transplant recipients are comparable to adults.
    • Younger children tend to have better outcomes, potentially due to lower rejection rates.
    • Adolescents face poor long-term outcomes, and bronchiolitis obliterans is a major late complication.

    Conclusions:

    • Pediatric lung transplantation is a viable option for severe lung diseases.
    • Addressing adherence issues in adolescents and managing bronchiolitis obliterans are critical for improving outcomes.
    • Multicenter studies and standardized protocols are necessary to advance pediatric transplant care.