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A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned
G P Mark1, D S Blander, B G Hoebel
1Department of Psychology, Princeton University, NJ 08544-1010.
Brain Research
|June 14, 1991
Abstract:
The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.