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Norepinephrine-stimulated phosphatidylinositol metabolism in genetically epilepsy-prone and kindled rats
D L Yourick1, M C LaPlaca, J L Meyerhoff
1Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Brain Research
|June 14, 1991
Abstract:
Genetically epilepsy-prone rats (GEPR-9) and kindled rats have reduced noradrenergic function. In the present study, norepinephrine-stimulated accumulation of inositol phosphates was reduced in cerebral cortex of GEPR-9 and kindled rats when compared to control and non-kindled rats, respectively. No such reduction was found in amygdala/pyriform cortex and hippocampus. These results support the hypothesis that cortical noradrenergic and associated second messenger systems are impaired in epilepsy.