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Related Experiment Video

Updated: Jun 26, 2026

Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
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The asymmetric vascular stent: efficacy in a rabbit aneurysm model.

Ciprian N Ionita1, Ann M Paciorek, Andreea Dohatcu

  • 1Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA. cnionita@buffalo.edu

Stroke
|January 10, 2009
PubMed
Summary

The asymmetrical vascular stent (AVS) effectively occluded intracranial aneurysms in a rabbit model, showing promise for aneurysm treatment. This novel device demonstrated superior performance compared to standard stents in promoting aneurysm thrombosis and healing.

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Last Updated: Jun 26, 2026

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07:04

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Published on: April 15, 2021

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Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

Area of Science:

  • Biomedical Engineering
  • Vascular Surgery
  • Medical Devices

Background:

  • Intracranial aneurysms pose significant treatment challenges.
  • Hemodynamic modifying devices are under active development.
  • The asymmetrical vascular stent (AVS) is a novel device designed to alter blood flow dynamics within aneurysms.

Purpose of the Study:

  • To evaluate the efficacy of the asymmetrical vascular stent (AVS) in treating intracranial aneurysms.
  • To compare AVS performance against standard coronary stents and untreated controls.
  • To assess aneurysm occlusion, flow dynamics, and histological changes post-treatment.

Main Methods:

  • Creation of 24 elastase-induced rabbit model aneurysms.
  • Treatment groups included AVS (n=13), standard coronary stents (n=5), and untreated controls (n=6).
  • Post-treatment assessment involved angiography, micro-CT, histology, and electron microscopy at 4 weeks.

Main Results:

  • AVS-treated aneurysms showed immediate and complete occlusion in all cases at follow-up.
  • Standard stent-treated aneurysms had incomplete occlusion and persistent flow in most cases.
  • Histology confirmed advanced thrombus organization in AVS-treated aneurysms, unlike controls.

Conclusions:

  • The asymmetrical vascular stent (AVS) demonstrates significant potential as a therapeutic device for intracranial aneurysms.
  • AVS promotes rapid aneurysm occlusion and organized thrombus formation.
  • Further research is warranted to support the clinical application of AVS.