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Updated: Jun 26, 2026

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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Reversible acute left ventricular dysfunction in accidental strangulation.

Sindhu Sivanandan1, Aditi Sinha, Rajnish Juneja

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|January 10, 2009
PubMed
Summary

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Accidental strangulation can cause temporary left ventricular dysfunction in children, mimicking a heart attack. This condition, linked to extreme sympathetic nervous system activation, is reversible with prompt medical care.

Area of Science:

  • Pediatric Cardiology
  • Critical Care Medicine
  • Cardiovascular Physiology

Background:

  • Strangulation incidents in children can lead to severe physiological stress.
  • Understanding the cardiac impact of strangulation is crucial for pediatric intensive care.

Observation:

  • A case report details an 8-year-old boy experiencing cardiogenic shock and pulmonary edema post-strangulation.
  • The patient presented with electrocardiogram abnormalities, elevated cardiac enzymes, and global left ventricular hypokinesia.

Findings:

  • Acute left ventricular dysfunction was observed, characterized by impaired heart muscle function.
  • Hemodynamic status and cardiac function significantly improved within 24 hours.
  • Resolution of electrocardiogram findings and left ventricular dysfunction confirmed the reversible nature of the condition.

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Related Experiment Videos

Last Updated: Jun 26, 2026

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
10:18

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Published on: February 1, 2022

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
05:48

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Published on: August 9, 2022

Implications:

  • Accidental strangulation can trigger exaggerated sympathetic responses, leading to acute myocardial dysfunction.
  • This cardiac dysfunction can mimic acute myocardial infarction in pediatric patients.
  • Prompt recognition and management are vital for favorable outcomes in strangulation-related cardiac events.