Urologic complications of HIV and AIDS
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Published on: October 6, 2016
Chris F Heyns1, Adam E Groeneveld, Nelson B Sigarroa
1University of Stellenbosch, Stellenbosch, South Africa. cfh2@sun.ac.za
Insights
Highly active antiretroviral therapy (HAART) transforms HIV infection into a manageable chronic condition. While HAART reduces mortality, urologic issues and the need for 100% effective HIV prevention remain challenges.
Area of Science:
- Urology
- Infectious Diseases
- Public Health
Background:
- HIV infection has shifted from a fatal disease to a chronic condition due to HAART.
- Untreated HIV leads to opportunistic infections and malignancies.
- HAART can cause urologic complications and aging-related conditions.
Purpose of the Study:
- To review the current understanding of HIV infection management and its urologic implications.
- To discuss the impact of HAART on disease progression and patient outcomes.
- To explore preventive strategies for HIV transmission.
Main Methods:
- Review of current literature on HIV/AIDS treatment and management.
- Analysis of clinical trial data regarding HAART efficacy and side effects.
- Examination of studies on male circumcision and HIV transmission rates.
Main Results:
- HAART significantly reduces HIV progression to AIDS and mortality.
- Urologic issues in HAART patients include medication side effects and age-related disorders.
- Male circumcision reduces female-to-male HIV transmission by over 50%.
Conclusions:
- HIV is now a chronic, manageable disease for those with HAART access.
- Urologic complications in HAART patients require careful management.
- Further research is needed for 100% effective HIV prevention strategies.
Abstract:
In recent years the nature of HIV infection has been dramatically transformed from an invariably fatal disease to a chronic disorder with a relatively benign course. Disease progression from HIV to AIDS and HIV-related mortality can be reduced effectively by several years of treatment with highly active antiretroviral therapy (HAART). For patients who do not have access to HAART, HIV infection continues to be a lethal disorder characterized by opportunistic infection with uncommon organisms (e.g. mycobacteria, fungi, parasites and viruses), as well as lethal malignancies such as Kaposi sarcoma, non-Hodgkin lymphoma and squamous cell carcinoma of the penis or cervix. In patients receiving HAART, urologic complications are likely to be caused by adverse effects of antiretroviral medication (e.g. indinavir urolithiasis) or disorders associated with aging, such as benign prostatic hyperplasia and prostate cancer. Prospective clinical trials have shown that adult male circumcision can reduce the rate of female to male HIV transmission by more than 50%; however, the development of preventive or curative modalities with 100% efficacy remains elusive.
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The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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