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Updated: Jun 26, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
[Blood coagulation disorders in children]
1Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital, Klinikum Innenstadt, Ludwig-Maximilians-Universität München.
Insights
Hemorrhagic or thrombotic events in children can stem from inherited or acquired causes, often appearing in infancy. Understanding pediatric-specific features is crucial for accurate diagnosis and effective treatment.
Area of Science:
- Pediatric Hematology
- Hemostasis and Thrombosis
Context:
- Hemorrhagic and thrombotic events are observed in pediatric populations, mirroring adult occurrences.
- The etiology of these events in children can be either congenital (inborn) or acquired.
- Inherited coagulation disorders typically manifest early in infancy.
Purpose:
- To highlight the importance of recognizing specific pediatric considerations in interpreting clinical and laboratory findings related to bleeding and clotting disorders.
- To underscore the necessity of this specialized knowledge for selecting appropriate therapeutic strategies in children.
Summary:
- Pediatric hemorrhagic and thrombotic events share similarities with adult presentations but possess unique underlying causes.
- Inborn conditions often present in early infancy, necessitating early diagnostic consideration.
- A thorough understanding of pediatric-specific hemostatic and thrombotic features is fundamental for accurate diagnosis and effective management.
Impact:
- Facilitates improved diagnostic accuracy for bleeding and clotting disorders in children.
- Guides the selection of optimal and tailored therapeutic interventions for pediatric patients.
- Enhances the overall management and clinical outcomes for children experiencing hemostatic and thrombotic complications.
Abstract:
As in adults, haemorrhagic or thrombotic events may also occur in children. The underlying reasons are inborn or acquired. Inherited disorders usually present during in early infancy. In order to interpret clinical and laboratory findings in children, it is necessary to keep in mind some specific paediatric features. This knowledge also forms the basic requirement to choose the appropriate therapy.
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