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Updated: Jun 26, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
Published on: April 19, 2017
Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease
Sophie J Bakri1, Jonathan E Sears, Gary W Procop
1Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA. sbakri@hotmail.com
Introduction:
The purpose is to report an eye with endogenous Aspergillus flavus endophthalmitis that achieved a good visual outcome following early and aggressive management.
Methods:
A 76-year-old male recently hospitalized for allergic Aspergillus pneumonitis after cleaning out a grain bin presented with reduced vision and anterior chamber and vitreous inflammation. The patient was treated with intravenous amphotericin and a pars plana vitrectomy with intravitreal amphotericin, and the vitreous biopsy sent for histopathological and microbial analysis.
Results:
A. flavus was isolated from the vitreous biopsy. Two weeks after vitrectomy, intravitreal amphotericin was again injected into the affected eye. The patient regained vision to 20/80 several months later, despite a moderate cataract.
Conclusion:
Early treatment of A. flavus endophthalmitis with pars plana vitrectomy, intravitreal and systemic amphotericin can lead to good visual outcomes.
Insights
Early and aggressive treatment of Aspergillus flavus endophthalmitis, including pars plana vitrectomy and amphotericin B, led to good visual recovery in a patient with fungal eye infection.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Reports a case of endogenous Aspergillus flavus endophthalmitis.
- Highlights the importance of prompt and aggressive management for favorable outcomes.
Observation:
- A 76-year-old male with allergic Aspergillus pneumonitis presented with vision loss and ocular inflammation.
- The patient underwent pars plana vitrectomy and received systemic and intravitreal amphotericin B.
Findings:
- Aspergillus flavus was identified in the vitreous biopsy.
- The patient achieved a final visual acuity of 20/80 despite developing a cataract.
Implications:
- Early intervention with surgical and medical treatment can preserve vision in Aspergillus endophthalmitis.
- This case underscores the potential for good visual outcomes with timely management of fungal endophthalmitis.
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