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07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[Acromegaly. Report of 84 cases]
Ignacio Alejandro Martínez-Delgado1, Graciela Gómez-Martínez
1Dirección de Educación e Investigación en Salud, Hospital de Cardiología 34, Centro Médico Nacional Monterrey, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, Mexico. ignacio.martinezd@imss.gob.mx
Revista Medica Del Instituto Mexicano Del Seguro Social
|January 10, 2009
Summary
Acromegaly, a rare disease of elevated growth hormone and IGF-1, is often diagnosed late. This leads to comorbidities and larger tumors, significantly lowering surgical cure rates to 7%.
Area of Science:
- Endocrinology
- Oncology
Context:
- Acromegaly is a rare endocrine disorder characterized by excessive growth hormone (GH) and insulin-like growth factor 1 (IGF-1) production.
- Surgical intervention is the primary treatment for acromegaly.
Purpose:
- To highlight the clinical significance of acromegaly.
- To encourage early specialist referral for timely diagnosis and treatment to prevent complications.
Summary:
- A review of 84 patients (1995-2005) found late diagnosis common.
- Frequent comorbidities included carbohydrate metabolism issues and hypertension; hypothyroidism was a common hormonal complication.
- Surgical cure rates were low at 7%, with 10% showing discordant GH and IGF-1 levels.
Impact:
- Late diagnosis of acromegaly is associated with comorbidities and larger tumor size, negatively impacting surgical outcomes.
- The study underscores the need for earlier detection and intervention to improve treatment success rates in acromegaly.
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