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Cardiac troponin-T in pre-end stage kidney disease

Songsak Kiatchoosakun1, Dujdao Sahasthas, Chaiyasith Wongvipaporn

  • 1Division of Cardiology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. sonkia@kku.ac.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|January 13, 2009
PubMed

Insights

Elevated cardiac troponin T (cTnT) is common in chronic kidney disease (CKD) stages 3-4, but levels above 0.1 microg/L are rare. Increased cTnT correlates with reduced kidney function, not left ventricular hypertrophy.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Chemistry

Background:

  • Cardiac troponin T (cTnT) elevations are frequent in end-stage chronic kidney disease (CKD).
  • Limited data exist on cTnT levels in pre-end-stage CKD patients.

Purpose of the Study:

  • To assess the relationship between cTnT levels and CKD severity in stages 3 and 4.
  • To investigate the association between left ventricular mass index (LVMI) and cTnT levels.

Main Methods:

  • 103 patients with CKD stages 3-4 underwent cTnT measurement using a third-generation immunoassay.
  • Echocardiography was performed to assess left ventricular hypertrophy (LVH), defined as LVMI > 125 g/m2.

Main Results:

  • 28.2% of patients had cTnT > 0.01 microg/L; 1.8% had cTnT > 0.1 microg/L.
  • Higher cTnT levels were observed in more severe CKD stages (stage 4 vs. stage 3).
  • No significant association was found between LVH and elevated cTnT (p=0.105).

Conclusions:

  • Elevated cTnT (> 0.01 microg/L) is common in non-dialysis CKD stages 3-4.
  • Serum cTnT levels exceeding 0.1 microg/L are uncommon in this population.
  • Increased cTnT is linked to reduced renal clearance but not LVH.
Abstract

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