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Related Concept Videos

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

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[Medicine in space. An organism under exceptional circumstances].

Medizinische Monatsschrift fur Pharmazeutenยท2008
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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
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[Nano-particles--pharmaceutical "dwarves" with know-how].

Andreas S Ziegler1

  • 1Apotheker und Wissenschaftsjournalist, Flurstrasse 2, 90613 Grosshabersdorf. andreas.s.ziegler@gmx.de

Medizinische Monatsschrift Fur Pharmazeuten
|January 13, 2009
PubMed
Summary

Nanotechnology is revolutionizing materials science and pharmacy. This field enables the development of advanced pharmaceutical preparations and innovative drug targeting solutions.

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences

Context:

  • The current decade is defined by 'nano' technology, following 'micro' and 'electronic' eras.
  • Nanomaterials are captivating both the public and scientific communities.
  • Advancements in nanotechnology are pushing boundaries in material capabilities.

Purpose:

  • To explore the application of nanotechnology in pharmaceutical formulations.
  • To address unresolved challenges in galenics and biopharmaceuticals.
  • To investigate novel drug targeting strategies using nanomaterials.

Summary:

  • Nanotechnology facilitates the creation of novel pharmaceutical preparations by operating at the nanoscale.
  • It provides innovative solutions for complex galenic and biopharmaceutical issues.

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  • The field opens up significant opportunities for targeted drug delivery systems.

    • Impact:

    • Enables the development of advanced materials like self-cleaning coatings and efficient mini fuel cells.
    • Revolutionizes drug formulation and delivery, leading to more effective treatments.
    • Offers potential for highly specific drug targeting, minimizing side effects and maximizing efficacy.