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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Characterizing impulsivity in mania.

Stephen M Strakowski1, David E Fleck, Melissa P DelBello

  • 1Division of Bipolar Disorders Research, Universtiy of Cincinnati College of Medicine, Cincinnati, OH, USA. stephen.strakowski@uc.edu

Bipolar Disorders
|January 13, 2009
PubMed
Summary
This summary is machine-generated.

Bipolar I manic patients show significant impulsivity deficits compared to healthy individuals, particularly in delaying gratification. These differences in reward valuation are key to understanding bipolar disorder.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Impulsivity is a core feature in bipolar disorder, manifesting in various forms.
  • Understanding specific impulsivity deficits is crucial for effective treatment strategies.

Purpose of the Study:

  • To compare distinct impulsivity aspects (response inhibition, delayed gratification, inattention) between bipolar I manic patients and healthy controls.
  • To investigate interrelationships among these impulsivity facets and their association with symptom severity.

Main Methods:

  • Utilized a stop signal task, delayed reward task, and continuous performance task to assess response inhibition, delayed gratification, and attention, respectively.
  • Compared performance of 70 bipolar I patients with 34 healthy subjects.
  • Analyzed correlations between task performance and symptom ratings, considering medication effects.

Main Results:

  • Bipolar subjects exhibited significant deficits across all three impulsivity tasks compared to controls.
  • Inability to delay gratification was independent of decision-making speed and inattention.
  • Response inhibition and attention measures were influenced by medication, while delayed gratification deficits were not.

Conclusions:

  • Bipolar I manic patients display notable deficits in multiple impulsivity domains compared to healthy individuals.
  • The inability to delay gratification in bipolar disorder appears linked to altered reward valuation, not solely decision speed or inattention.
  • Medication may influence certain impulsivity measures, but delayed gratification differences persist independently.