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[A prospective study for systemic inflammatory response syndrome (SIRS) after cerebral infarction]
Yuan-yuan Xue1, Xiao-yun Xu, Gang Li
1Department of Neurology, East Hospital, Tongji University, Shanghai 200120, China.
Objective:
To investigate whether systemic inflammatory response syndrome (SIRS) after cerebral infarction is associated with poor outcome and its associated clinical factors.
Methods:
We prospectively studied 500 patients with cerebral infarction, recorded the associated clinical factors on presentation and calculated the mortality at 21st day.
Results:
There are 85 SIRS patients in 500 patients with cerebral infarction, 31 with total anterior cerebral infarction (TACI), 34 with partial anterior cerebral infarction (PACI), 15 with posterior cerebral infarction (POCI) and 5 with lacunar cerebral infarction (LACI). The frequency of SIRS was positively correlated with mortality rate according to Oxfordshire Community Stroke Project (OCSP) subtypes in cerebral infarction patients with fever (Spearman correlation coefficient = 1.0; P < 0.001). Single factor analysis showed that the risk factors for both SIRS and mortality of cerebral infarction were as follows: age, infection, 48 h Chinese Stroke Scale score, 48 h Glasgow score, OCSP subtypes and dysphagia. Diabetes was the risk factor for SIRS, but had no effect on mortality. On Cox regression, 48 h Glasgow score was the sole independent risk factor of outcome. However, if SIRS was included in the formula, P > 0.05.
Conclusions:
SIRS is the predictor of poor outcome after acute cerebral infarction. It is important to prevent SIRS especially in TACI and POCI. Diabetes is the risk factor for SIRS, but has no effect on mortality.
