Fine structural studies of a human thyroid adenoma, with special reference to psammoma bodies

The fine structural morphologic features of a microfollicular thyroid adenoma from a 28 year old female were examined. Although the patient had been laking exogenous thyroxine therapy for 14 months, the morphology of the adenoma was characterized by numerous small to medium sized follicles composed of metabolically active, well differentiated columnar cells with numerous colloid droplets, dilated granular endoplasmic reticulum, large numbers of coated vesicles and lysosomes, large colloid containing "lakes," microtubules, microfilaments, and prominent apical microvillous projections. Of special inetrest were small spherical psammomatous calcospherites ecountered in histiocytes and the interstitium. Also noteworthy were ropelike configurations observed in most of the follicular lumina. Structural-functional correlations and potential origins of psammoma bodies and calcospherites are discussed.