Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Science, medicine and ethics during COVID-19 pandemic.

Acta paediatrica (Oslo, Norway : 1992)·2021
Same author

Return to School for Children With Tracheostomy or Requiring Noninvasive Ventilation Lessons From the First Lockdown in the United Kingdom.

Chest·2021
Same author

Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper.

Allergy·2021
Same author

E-Cigarettes as a Growing Threat for Children and Adolescents: Position Statement From the European Academy of Paediatrics.

Frontiers in pediatrics·2021
Same author

COVID-19 and delivery of difficult asthma services.

Archives of disease in childhood·2021
Same author

Electronic reminders and rewards to improve adherence to inhaled asthma treatment in adolescents: a non-randomised feasibility study in tertiary care.

BMJ open·2021
Same journal

Barriers, Breakthroughs, and the Future of Pediatric Dermatologic Care.

Pediatric clinics of North America·2026
Same journal

Advancing Pediatric Dermatology: Innovations in Care and Access.

Pediatric clinics of North America·2026
Same journal

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026
Same journal

Telemedicine and Access to Pediatric Dermatology Care.

Pediatric clinics of North America·2026
Same journal

Inequitable Reimbursement for Pediatric Providers: A Review of Structural Factors that Disincentivize the Care of Children.

Pediatric clinics of North America·2026
Same journal

Medical Photography's Power to Change Medical Care.

Pediatric clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 11, 2013

Recurrent respiratory infections.

Andrew Bush1

  • 1Imperial School of Medicine at National Heart and Lung Institute, London, UK. a.bush@rbh.nthames.nhs.uk

Pediatric Clinics of North America
|January 13, 2009
PubMed
Summary
This summary is machine-generated.

Diagnosing recurrent infections in children is challenging. This guide offers an experience-based approach for clinicians to differentiate serious illness from normal development and select the least invasive diagnostic tests.

More Related Videos

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

Related Experiment Videos

Last Updated: Jun 18, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 11, 2013

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

Area of Science:

  • Pediatrics
  • Immunology
  • Clinical Diagnostics

Background:

  • Recurrent infections in children present significant diagnostic difficulties for pediatricians.
  • Clinicians must first assess if a child's condition is normal or indicative of serious disease.
  • Subsequent diagnostic steps require careful consideration to minimize invasiveness.

Purpose of the Study:

  • To provide a practical, experience-based guide for diagnosing children with recurrent infections.
  • To assist clinicians in differentiating between normal development and serious underlying conditions.
  • To outline a strategy for selecting the most appropriate and least invasive diagnostic tests.

Main Methods:

  • This article proposes an experience-based clinical approach, acknowledging the lack of extensive high-quality evidence.
  • It focuses on a systematic evaluation process for children presenting with recurrent infections.
  • The approach emphasizes a tiered strategy for diagnostic testing.

Main Results:

  • The article offers a framework to aid clinicians in the diagnostic process for recurrent infections.
  • It aims to reduce uncertainty in distinguishing between benign and serious conditions.
  • Guidance is provided on minimizing the number and invasiveness of diagnostic tests.

Conclusions:

  • An experience-based approach can be a valuable tool for clinicians managing children with recurrent infections.
  • Effective diagnosis requires a careful initial assessment and judicious use of diagnostic tests.
  • This strategy aims to improve diagnostic accuracy while prioritizing patient comfort and minimizing unnecessary procedures.